KMID : 0379120060340020105
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Korean Journal of Mycology 2006 Volume.34 No. 2 p.105 ~ p.111
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The Immuno-Modulatory and Antitumor Effects of Crude Polysaccharides Extracted from Tremella fuciformis
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Oh Yoon-Hee
No Hyun-Soo Lee Hyun-Sook Kim Sang-Bum Lee Geon-Woo Kim Hye-Young Shim Mi-Ja Lee Min-Woong Lee Woo-Yoon Lee Tae-Soo
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Abstract
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Tremella fuciformis, one of edible and medicinal mushroom belonging to Tremellaceae of Basidiomycota, has been known to have a curative effect on sarcoma 180 of mice and lowering high blood pressure of human beings. Neutral salt soluble [0.9% NaCl (Fr. NaCl)], hot water soluble (Fr. HW) and methanol soluble (Fr. MeOH) substances were extracted from Tremella fuciformis. In vitro cytotoxicity tests, Fr. HW and Fr. NaCl were not cytotoxic against cancer cell lines such as NIH3T3, Sarcoma 180, and HT-29 at the concentration of $2000{\mu}g/ml$, while Fr. MeOH was cytotoxic to NIH3T3 and Sarcoma 180. Intraperitoneal injection with Fr. NaCl showed antitumor effect with life prolongation of 53% in mice inoculated with Sarcoma 180. Fr. NaCl improved the immunopotentiation activity of B lymphocyte by increasing the alkaline phosphatase activity by $3.0{\sim}8.1$ folds, respectively. Intraperitoneal injection with Fr. NaCl increased the numbers of peritoneal exudated cells and circulating leukocytes by 7.4 folds and 1.6 folds, respectively, than in the control group. The antitumor effect of T. fuciformis against Sarcoma 180 of mice was likely due to immunopotentiation activity.
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KEYWORD
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Antitumor effect, Crude polysaccharides, Immuno-modulatory, Tremella fuciformis
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